A significant step for solving large medical problem, which is increasing resistance of bacteria to antibiotics, scientists have made of Medicine and Science, Palacky University. Demonstrated that the efficacy of antibiotics increases the addition of a silver compound, or microparticles or nanoparticles of metal. Antibiotics in combination with silver may then be used in lower doses and act on bacteria that were previously resistant to antibiotics.
Long-term overuse of antibiotics accompanied medicine especially in the 60s and 80s of the last century. * „Many bacterial strains have become resistant to antibiotic treatment, or to suppress bacterial infections are often needed significantly higher doses of antibiotics and their combinations. It brings with it a number of adverse effects including drug interactions,“ explained the reasons for * years of research and dean of the Faculty of Medicine microbiologist Milan Kolar, who participated in the research.
The essence of Olomouc invention, the process is already registered for patenting the Industrial Property Office of the Czech Republic, is a preparation containing a mixture of antibiotics and silver nanoparticles or appropriate compounds. Benefit lies in the fact that antibiotics again with addition of silver exhibit antibacterial activity even against such bacteria without antibiotic to which the dopant does not become or has been only partially effective. The effect can be demonstrated even at substantially lower concentrations of antibiotics.
** The antibacterial effects of silver known in antiquity **
Scientists have confirmed the first antibacterial activity of silver. Work published in 2006 in the journal The Journal of Physical Chemistry B among the first work of this kind, met with great acclaim in the professional world and already has hundreds of citations. Then came the question of the resistance of bacteria to antibiotic treatment, which scientists employed in the past about three years. * "It occurred to us to add antibiotics nanoparticles. We were able to demonstrate that silver nanoparticles greatly enhance the effect of antibiotics against bacteria. In practice, this allows to use smaller doses of antibiotics in combination with silver, thereby reducing the risk of side effects. Perhaps even more important is the finding that silver nanoparticles renewing effect of antibiotics against resistant bacteria, "* said Panáček.
** Scientists expect a number of clinical trials ** Silver nanoparticles are still in treating bacterial infections do not. To become part of future drugs will be necessary to make a number of clinical trials, which are very expensive. According to Kolar principle was verified in laboratory conditions. * „Efficacy has been proven even when applied topically as an ointment, and hydrogels. Currently, research continues animal testing,“ * said Kolar.
The combination of antibiotics and silver nanoparticles investigated in the past and other scientific teams. * "In no case did not reach such important results as we do, that such a high antibacterial activity at concentrations as low silver nanoparticles and antibiotics. It is a fact that we have a connection through teams of researchers from nanomaterials research and microbiological research unique method for the preparation of silver nanoparticles and also a very reliable method of testing the antibacterial activity. Therefore, our teams came to the forefront of research in the field of restoration of sensitivity yet resistant bacteria to antibiotics, "* thinks Panáček.
The latest results are expected in the immediate future appear in the literature. Antibiotic therapy in combination with silver could find application not only in human medicine but also veterinary medicine, medical devices and materials or in cosmetics.
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Assistant Professor Department of Physical Chemistry E-mail: firstname.lastname@example.org Tel .: 585 634 427 *
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