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Scientists at the Veterinary University in Brno Faculty of Pharmaceutical searched genes that might be complicit in an outbreak of inflammatory diseases of the digestive tract Added:18.10. 2010
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Scientists at the Veterinary University in Brno Faculty of Pharmaceutical searched genes that might be complicit in an outbreak of inflammatory diseases of the digestive tract

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Pharmacologists of the Institute of Human Pharmacology and Toxicology and Institute of Natural Drugs VFU Brno, Faculty of Pharmacy in his study focused on searching for genes that could contribute to the likelihood of an outbreak of gastrointestinal disease such as Crohn's disease or ulcerative colitis (inflammation of the colon) – chronic inflammatory diseases , which is appearing more and more especially among young people.

The number of sick persons suffering from inflammatory bowel inflammation in western Europe is growing year by year. Although not yet comprehensively describes the causes and mechanisms that lead to the emergence and development of diseases of the digestive tract, is now generally accepted that inflammatory bowel diseases are diseases with a genetic basis, with the effect of the external environment (such as stress, infectious environment, etc.), becomes the only factor triggering the disease.

Scientists at the Veterinary University in Brno Faculty of Pharmacy is currently focused on monitoring the presence of certain genes and mutations and their influence on the outbreak of Crohn's disease and inflammatory colitis. In the study they were able to demonstrate that the genetic makeup of man truly determine the risk of outbreaks of these diseases. Genetic predisposition of disease is usually associated with the presence of specific changes in the NOD2/CARD15 gene in human DNA. The researchers performed genetic analysis of more than 130 patients diagnosed with Crohn's disease and colitis, and come up with clear results:

  • "Our results suggest that patients with Crohn's disease is statistically more frequently than in the healthy population occurs in the gene replacement mutation of ICAM-1 and frameshift mutations in the NOD2/CARD15 gene. In patients with ulcerative colitis, we found significantly more frequent substitution mutation in the gene ICAM-1 compared to healthy volunteers, "says Dr. *. Ladislav Bartosova Ph.D. Department of Human Pharmacology and Toxicology Pharmaceutical Faculty of Veterinary University in Brno.

Likewise, the study showed that the disease is more frequent for younger patients. * "Our results point to the fact that the younger patients, the more they greater genetic predisposition to disease, "adds Dr. * Bartosova.

Inflammatory bowel diseases are currently incurable diseases, but with modern drugs can often be successfully controlled. Treatment is strictly individual, depending on the degree and extent of disability. Results from the study of pharmacologists VFU Brno, Faculty of Pharmacy can help in developing more effective drugs and also to determine the correct drug treatment and systemic treatment for the patient. Evidence of genetic predisposition to this disease because it may bring the patient to the doctor and subsequent treatment much sooner than if the patient knows what is causing the problems.

  • Research was conducted at the Institute of Human Pharmacology and Toxicology and Institute of Natural Drugs VFU Brno, Faculty of Pharmacy in cooperation with the Internal hepato-gastroenterology clinic of University Hospital Brno and III. Internal Clinic, University Hospital of Academician L. Dérer Bratislava .*

** For more information contact: **

** Veterinary and Pharmaceutical Sciences ** Lucy Stejskalová Spokesperson Tel: +420 541 562 010, mobile: +420 724 321 352, E-mail: stejskaloval@vfu.cz www.vfu.cz




Author: tiskove, zpravy

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